By Christophe Poncelet
Cet ouvrage de r?f?rence r?unit les principaux specialists nationaux et parfois internationaux des diff?rentes sp?cialit?s de l. a. replica. l. a. premi?re partie passe en revue les donn?es fondamentales de l. a. physiologie et retrace l'histoire de l'assistance m?dicale ? l. a. procr?ation. Sont abord?s ensuite les features ?pid?miologiques et surtout m?dico-l?gaux. Un chapitre complet d?taille le diagnostique, le pronostique et les traitements chirurgicaux. Les innovations les plus r?centes d'assistance m?dicale ? l. a. procr?ation sont ensuite pass?es en revue, de m?me que les proc?d?s de cryopr?servation. L'ouvrage fait enfin une huge position aux consid?rations transversales (cancer, pathologies auto-immunes, implications ?thiques, etc.) mais essentielles autour de los angeles fertilit? et de l'infertilit?, et de son effect psychologique sur les undefined.
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Additional info for Physiologie, pathologie et thérapie de la reproduction chez l'humain
The function of progesterone is to induce the necessary changes needed for endometrial receptivity and anticipation of embryo implantation. Progesterone promotes mammary gland development, increases uterine gland secretion, and inhibits uterine motility to promote implantation and sustain pregnancy. High levels of progesterone decrease LH pulse frequency and cause turnover of non-ovulatory dominant follicles. After its functional span, the CL spontaneously regresses, to be replaced (unless pregnancy occurs) by an avascular scar referred as the ‘corpus albicans’.
As shown by Senger et al. (84), the suppression of VEGF leads to almost complete suppression of CL formation. The CL is a temporary endocrine gland, which mainly secretes progesterone but also E2. Serum progesterone levels increase as CL grows and develops, and are used in clinical practice as one of the diagnostic biomarkers of ongoing pregnancy. The function of progesterone is to induce the necessary changes needed for endometrial receptivity and anticipation of embryo implantation. Progesterone promotes mammary gland development, increases uterine gland secretion, and inhibits uterine motility to promote implantation and sustain pregnancy.
Quantitative real-time PCR can be integrated in the evaluation of cultured follicles. This approach is more appropriated for isolated follicles (203, 204). The conditioned media collected at each time point of culture can provide information as to the degree of somatic cell differentiation in vitro. Several secretion products can be measured to evaluate follicle growth during culture. For instance, absence or low estrogen (E2) production could be related to either absence or incomplete aromatization in granulosa cells or to the non-functionality of the theca compartment.
Physiologie, pathologie et thérapie de la reproduction chez l'humain by Christophe Poncelet