By Sashwati Roy, Debasis Bagchi, Siba P. Raychaudhuri

ISBN-10: 1439872155

ISBN-13: 9781439872154

Content material: part 1. platforms biology of irritation and regulatory mechanisms -- part 2. Pathologies linked to irritation -- part three. food & therapeutics for inflammatory ailments

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In another example, an ABM was created to examine the response of inflammatory cells and cells involved in remodeling to particulate exposure (combined with experimental smoke inhalation in mice), focusing on TNF-α, TGF-β1, collagen deposition, and tissue damage/DAMPs; this study may improve the understanding of lung diseases such as chronic obstructive pulmonary disease (COPD) [26]. Another inflammatory/fibrotic lung disease that was examined using ­equation-based modeling is sarcoidosis; in that study, the authors utilized a similar approach to the one used in modeling COPD, in that they varied model parameters in order to define key controlling processes in this disease [5].

Redd MJ, Cooper L, Wood W, Stramer B, Martin P: Wound healing and inflammation: Embryos reveal the way to perfect repair. Philos Trans R Soc Lond B Biol Sci 2004, 359:777–784. 125. Reynolds A, Rubin J, Clermont G, Day J, Vodovotz Y, Ermentrout GB: A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol 2006, 242:220–236. 126. Richardson M: Acute wounds: An overview of the physiological healing process. Nurs Times 2004, 100:50–53.

These processes can be modeled computationally using both data-driven and mechanistic approaches. • Acute inflammation is comprised of fast feedback loops that can activate adaptive immunity, which in turn is both regulated by slower internal feedback loops and affects acute inflammation through these slower feedback loops. Modeling Acute and Chronic Inflammation 13 • Both acute and chronic inflammatory processes share and invoke key elements and functions, thereby helping explain why drugs nominally targeting acute inflammation work well in chronic diseases such as rheumatoid arthritis, while nominal elements of adaptive immunity are activated early in acute states such as sepsis and trauma.

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Chronic inflammation : molecular pathophysiology, nutritional and therapeutic interventions by Sashwati Roy, Debasis Bagchi, Siba P. Raychaudhuri


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