By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the commonest toxicological aim within the endocrine process, the adrenal gland has frequently been ignored in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations on hand to envision adrenal endocrine disruption.

Examining present suggestions and the newest developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of gear and chemical compounds that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro review. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the key advancements revamped the previous decade
  • focuses at the most up-to-date examine concepts, together with their makes use of and limitations
  • provides an built-in approach for adrenal toxicology evaluation
  • identifies wisdom and information gaps, supplying impetus for regulatory consideration

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Sample text

Baldwin (1996) reviews the role of natural and synthetic glucocorticosteroids in development and developmental toxicity in laboratory species and humans. , 2007). The strategy is based on a short in vivo study where the competence of the adrenal in treated rodents is assessed by an ACTH challenge and resulting corticosterone secretion is measured in the blood as an endpoint marker of adrenocortical function. , 2007). The ability of untreated rats to respond to an ACTH challenge by markedly increased corticosterone secretion, compared with test compound treated rats that cannot respond, would provide strong evidence of adrenocortical suppression.

Potts GO, Creange JE, Harding HR, et al. Trilostane, an orally active inhibitor of steroid biosynthesis. Steroids 1978; 32:257–267. 32 Harvey et al. Quabius ES, Balm PH, Wendelaar Bongar SE. Inter-renal stress responsiveness of tilapia (Oreochromis mossambicus) is impaired by dietary exposure to PCB126. Gen Comp Endocrinol 1997; 108:472–482. Rao ChV, Zhou XL, Lei, ZM. Functional luteinizing hormone/chorionic gonadotrophin receptors in human adrenal cortical H295R cells. Biol Reprod 2004; 71:579–587.

Biol Reprod 2001; 65:1252–1259. Albertson BD, Hill RB, Sprague KA, et al. Effects of the antiglucocorticoid RU486 on adrenal steroidogenic enzyme activity and steroidogenesis. Eur J Endocrinol 1994; 130:195–200. Andersen HR, Vingaard AM, Rasmusse TH, et al. Effects of currently used pesticides in assays for estrogenicity and aromatase activity in vitro. Toxicol Appl Pharmacol 2000; 179:1–12. Baldwin JA. Glucocorticosteroids, stress, and developmental toxicology. In: Harvey PW, ed. The adrenal in toxicology: Target organ and modulator of toxicity.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


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