By H.A. Delemarre-van de Waal, P.-E. Mullis

ISBN-10: 142371394X

ISBN-13: 9781423713944

ISBN-10: 3318011789

ISBN-13: 9783318011784

This e-book on abnormalities in puberty offers an summary at the newest wisdom at the mechanisms of the developmental techniques of puberty. even supposing the precise mechanisms of reawakening of the GnRH pulse generator on the onset of puberty nonetheless need to be elucidated, many genetic and environmental elements were pointed out to play a massive function. issues mentioned in person chapters contain the endocrine and metabolic matters on the topic of the 'developmental foundation of grownup illness' speculation and polycystic ovary syndrome in addition to abnormalities in GnRH controlling genes, GnRH-secreting hamartoma as a version for the onset of puberty, adventure at the program of GnRH analogues within the remedy of imperative precocious puberty, and the psychosocial results of an early puberty. This quantity presents the paediatrician, endocrinologist, gynaecologist and healthcare professional with underlying info in addition to functional tokens on find out how to deal with some of the stipulations of a disturbed technique of puberty.

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5 mg/kg reduced birthweight by 11%, and three doses given weekly reduced birthweight by 19–25% [9]. The effects of more modest levels of antenatal glucocorticoid exposure on growth rates are not clear (discussed below), but could contribute to early suppression of adrenal function in the newborn [5]. Glucocorticoid Deficiency in the Low-Birthweight Newborn Low circulating cortisol levels and adrenocortical insufficiency during the first few postnatal days are particularly seen among ill very-low-birthweight (VLBW: Ͻ1,500 g) premature infants, and are a cause of hypotension that is resistant to volume and inotrope support [10, 11].

In that study, lower 11␤-HSD2 activity was also associated with increased umbilical artery resistance, and it is possible that lower enzyme activity might represent a stress response to other causes of fetal growth restraint [57]. Associations between common functional variants in the 11␤-HSD1 or 11␤-HSD2 genes [58] could further demonstrate the importance of 11␤-HSD activity to the links between fetal growth and long-term disease risks. Adrenal Function of Low-Birthweight Children 41 Programming of Adrenal Androgen Production The adrenal androgens, dehydroepiandrosterone (DHEA) and DHEAsulfate (DHEAS), are produced by the adrenal zona reticularis [59], and circulating DHEAS levels provide a convenient marker of rate of adrenal androgen production [60].

Previous studies in boys showed a positive relationship between age at onset of puberty and BMI [49]. 5 years in SGA boys were comparable to AGA boys. CA/PA ϫ 100%, however, was Ͼ100 in SGA boys indicating that a certain pubertal stage was reached relatively late for their calendar age. Animal studies also show a delayed onset of puberty in IUGR male rats [41]. The clinical relevance of such delay is not known yet. However, an association between male gonadal dysfunction and severely reduced fetal growth has been long recognized [50, 51].

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Abnormalities in puberty : scientific and clinical advances by H.A. Delemarre-van de Waal, P.-E. Mullis


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