By National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee
In 2005, the nationwide Academies published the document guidance for Human Embryonic Stem cellphone examine, which provided a typical set of moral criteria for a box that, as a result absence of entire federal investment, was once missing nationwide criteria for research.
In order to maintain the tips modern, given the swift speed of clinical advancements within the box of stem cellphone examine, the Human Embryonic Stem mobile examine Advisory Committee used to be proven in 2006 with help from The Ellison clinical origin, The Greenwall beginning, and the Howard Hughes scientific Institute.
As it did in 2007, the Committee pointed out matters that warranted revision, and this booklet addresses these concerns in a moment set of amendments. most significantly, this ebook addresses new medical advancements in reprogramming of somatic cells to pluripotency through including a brand new part and revising different suitable sections of the Guidelines.
Read Online or Download 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research PDF
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Additional info for 2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research
0 BANKING AND DISTRIBUTION OF hES CELL LINES There are several models for the banking of human biological materials, including hES cells. K. Stem Cell Bank. The guidelines developed by this and other groups generally adhere to key ethical principles that focus on the need for consent of donors and a system for monitoring adherence to ethical, legal, and scientific requirements. As hES cell research advances, it will be increasingly important for institutions that are obtaining, storing, and using cell lines to have confidence in the value of stored cells—that is, that they were obtained ethically and with the informed consent of donors, that they are well characterized and screened for safety, and that the conditions under which they are maintained and stored meet the highest scientific standards.
4 Multipotent Neural Stem Cells It is also relevant to note that neural stem cells, although not pluripotent, are multipotent and may have the potential to contribute to neural tissue in chimeric animals. ESCRO committees should decide whether they wish to review and monitor such experiments with neural stem cells in a similar fashion. 5 Prohibition on Breeding No animal into which hPS cells have been introduced such that they could contribute to the germ line should be allowed to breed. 6 Guidance for Banking and Distribution Institutions should consider the value of banking and distributing hPS cells using the guidance and rules that are already in place for hES cells and the value of including hPS cell lines in their registries.
Fertilization—The process whereby male and female gametes unite to form a zygote (fertilized egg). Fibroblasts—Cells from many organs that give rise to connective tissue. Gamete—A mature male or female germ cell, that is, sperm or oocyte, respectively. Gastrulation—The procedure by which an animal embryo at an early stage of development produces the three primary germ layers: ectoderm, mesoderm, and endoderm. Gene—A functional unit of heredity that is a segment of DNA located in a specific site on a chromosome.
2008 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research by National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Human Embryonic Stem Cell Research Advisory Committee